abstract：BACKGROUND:In view of the close relationship of Portugal with African countries, particularly former Portuguese colonies, the diagnosis of malaria is not a rare thing. When a traveller returns ill from endemic areas, malaria should be the number one suspect. World Health Organization treatment guidelines recommend that...

journal_title：Malaria journal

authors： Santos LC,Abreu CF,Xerinda SM,Tavares M,Lucas R,Sarmento AC

更新日期：2012-03-29 00:00:00

abstract：BACKGROUND:Control of mosquitoes that transmit malaria has been the mainstay in the fight against the disease, but alternative methods are required in view of emerging insecticide resistance. Entomopathogenic fungi are candidate alternatives, but to date, few trials have translated the use of these agents to field-base...

journal_title：Malaria journal

authors： Mnyone LL,Lyimo IN,Lwetoijera DW,Mpingwa MW,Nchimbi N,Hancock PA,Russell TL,Kirby MJ,Takken W,Koenraadt CJ

更新日期：2012-03-26 00:00:00

abstract：BACKGROUND:Plasmodium falciparum malaria is a significant problem around the world today, thus there is still a need for new control methods to be developed. Because the sporozoite displays dual infectivity for both the mosquito salivary glands and vertebrate host tissue, it is a good target for vaccine development. M...

journal_title：Malaria journal

authors： Schlarman MS,Roberts RN,Kariuki MM,LaCrue AN,Ou R,Beerntsen BT

更新日期：2012-03-23 00:00:00

abstract：BACKGROUND:Anopheles baimaii is a primary vector of human malaria in the forest settings of Southeast Asia including the north-eastern region of India. Here, the genetic population structure and the basic population genetic parameters of An. baimaii in north-east India were estimated using DNA sequences of the mitochon...

journal_title：Malaria journal

authors： Sarma DK,Prakash A,O'Loughlin SM,Bhattacharyya DR,Mohapatra PK,Bhattacharjee K,Das K,Singh S,Sarma NP,Ahmed GU,Walton C,Mahanta J

更新日期：2012-03-20 00:00:00

abstract：BACKGROUND:Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for...

journal_title：Malaria journal

authors： Drame PM,Machault V,Diallo A,Cornélie S,Poinsignon A,Lalou R,Sembène M,Dos Santos S,Rogier C,Pagès F,Le Hesran JY,Remoué F

更新日期：2012-03-16 00:00:00

abstract：BACKGROUND:Increasing access to health care services is considered central to improving the health of populations. Existing reviews to understand factors affecting access to health care have focused on attributes of patients and their communities that act as 'barriers' to access, such as education level, financial and ...

journal_title：Malaria journal

authors： Kizito J,Kayendeke M,Nabirye C,Staedke SG,Chandler CI

更新日期：2012-02-23 00:00:00

abstract：:Genetic manipulation of malaria parasites remains an inefficient, time-consuming and resource-intensive process. Presented here is a set of methods for 96-well plate-based transfection and culture that improve the efficiency of genetic manipulation of Plasmodium falciparum. Compared to standard protocols plate-based t...

journal_title：Malaria journal

authors： Caro F,Miller MG,DeRisi JL

更新日期：2012-01-18 00:00:00

abstract：BACKGROUND:Malaria is endemic in the Rajasthali region of the Chittagong Hill Tracts in Bangladesh and the Rajasthali region is the most endemic area of Bangladesh. Quantifying the role of environmental and socio-economic factors in the local spatial patterns of malaria endemicity can contribute to successful malaria c...

journal_title：Malaria journal

authors： Haque U,Soares Magalhães RJ,Mitra D,Kolivras KN,Schmidt WP,Haque R,Glass GE

更新日期：2011-12-15 00:00:00

abstract：BACKGROUND:The diagnosis of malaria can be difficult in non-endemic areas, such as the United States, and delays in diagnosis and errors in treatment occur too often. METHODS:A nationwide survey of laboratories in the United States and its nine dependent territories was conducted in 2010 to determine factors that may ...

journal_title：Malaria journal

authors： Abanyie FA,Arguin PM,Gutman J

更新日期：2011-11-10 00:00:00

abstract：BACKGROUND:Policy makers, governments and donors are faced with an information gap when considering ways to improve access to artemisinin-based combination therapy (ACT) and malaria diagnostics including rapid diagnostic tests (RDTs). To help address some of these gaps, a five-year multi-country research project called...

journal_title：Malaria journal

authors： Shewchuk T,O'Connell KA,Goodman C,Hanson K,Chapman S,Chavasse D

更新日期：2011-10-31 00:00:00

abstract：BACKGROUND:Counts of malaria parasites in peripheral blood are important to assess severity of Plasmodium falciparum malaria. Thin and thick smears are routinely used for this purpose. METHODS:In this study the Binax NOW Malaria Test, an easy-to-perform rapid diagnostic test, with Histidine Rich Protein-2 (HRP-2) and ...

journal_title：Malaria journal

authors： van Gool T,van Wolfswinkel ME,Koelewijn R,van Thiel PP,Jacobs J,van Hellemond JJ,van Genderen PJ

更新日期：2011-10-14 00:00:00

abstract：BACKGROUND:In 2009, Santa Isabel Province in the Solomon Islands embarked on a malaria elimination programme. However, very little is known in the Province about the anopheline fauna, which species are vectors, their bionomics and how they may respond to intensified intervention measures. The purpose of this study was ...

journal_title：Malaria journal

authors： Bugoro H,Iro'ofa C,Mackenzie DO,Apairamo A,Hevalao W,Corcoran S,Bobogare A,Beebe NW,Russell TL,Chen CC,Cooper RD

更新日期：2011-09-30 00:00:00

abstract：:Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild to severe malaria infection. Given the therapeutic significance of AS and the necessity of appropriate AS dosing, substantial research has been performed investigating the pharmacokinetics of AS and its active metabolit...

journal_title：Malaria journal

authors： Morris CA,Duparc S,Borghini-Fuhrer I,Jung D,Shin CS,Fleckenstein L

更新日期：2011-09-13 00:00:00

abstract：BACKGROUND:The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern. Despite the importance in understanding genetic diversity for control strategies, however, studies remain inconclusive with the general premise that due to low rate of malaria transmission, there is gene...

journal_title：Malaria journal

authors： Honma H,Kim JY,Palacpac NM,Mita T,Lee W,Horii T,Tanabe K

更新日期：2011-09-07 00:00:00

abstract：BACKGROUND:Many malaria-related studies depend on infected red blood cells (iRBCs) as fundamental material; however, infected blood samples from human or animal models include leukocytes (white blood cells or WBCs), especially difficult to separate from iRBCs in cases involving Plasmodium vivax. These host WBCs are a s...

journal_title：Malaria journal

authors： Tao ZY,Xia H,Cao J,Gao Q

更新日期：2011-08-25 00:00:00

abstract：BACKGROUND:Real-time PCR is a sensitive and specific method for the analysis of Plasmodium DNA. However, prior purification of genomic DNA from blood is necessary since PCR inhibitors and quenching of fluorophores from blood prevent efficient amplification and detection of PCR products. METHODS:Reagents designed to sp...

journal_title：Malaria journal

authors： Taylor BJ,Martin KA,Arango E,Agudelo OM,Maestre A,Yanow SK

更新日期：2011-08-19 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate whether a selection of South African ethnomedicinal plants included in this study displayed insecticidal properties when screened against adult stages of the mosquito. METHODS:381 crude extracts of 80 plant taxa in 42 families were sprayed onto ceramic tiles and screened...

journal_title：Malaria journal

authors： Maharaj R,Maharaj V,Crouch NR,Bhagwandin N,Folb PI,Pillay P,Gayaram R

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:Malaria is a major public health issue in Burundi in terms of both morbidity and mortality, with around 2.5 million clinical cases and more than 15,000 deaths each year. It is still the single main cause of mortality in pregnant women and children below five years of age. Because of the severe health and eco...

journal_title：Malaria journal

authors： Nkurunziza H,Gebhardt A,Pilz J

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the profile of antibodies against several antigens of Plasmodium vivax and Plasmodium falciparum in Mandalay, Myanmar. METHODS:Malaria parasites were identified by microscopic examination. To test the antibodies against P. vivax and P. falciparum in sera, an indirect...

journal_title：Malaria journal

authors： Kim TS,Kim HH,Kim JY,Kong Y,Na BK,Lin K,Moon SU,Kim YJ,Kwon MH,Sohn Y,Kim H,Lee HW

更新日期：2011-08-06 00:00:00

abstract：BACKGROUND:There has been much debate about the appropriate statistical methodology for the evaluation of malaria field studies and the challenges in interpreting data arising from these trials. METHODS:The present paper describes, for a pivotal phase III efficacy of the RTS, S/AS01 malaria vaccine, the methods of the...

journal_title：Malaria journal

authors： Lievens M,Aponte JJ,Williamson J,Mmbando B,Mohamed A,Bejon P,Leach A

更新日期：2011-08-04 00:00:00

abstract：BACKGROUND:Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the compound exhibits slow parasite and fever clearance times, and toxicity in glucose-6-phosphate dehydrogenase (G6PD) deficiency is a concern. Combinati...

journal_title：Malaria journal

authors： Dow GS,Gettayacamin M,Hansukjariya P,Imerbsin R,Komcharoen S,Sattabongkot J,Kyle D,Milhous W,Cozens S,Kenworthy D,Miller A,Veazey J,Ohrt C

更新日期：2011-07-29 00:00:00

abstract：BACKGROUND:Malaria is reportedly receding in different epidemiological settings, but local long-term surveys are limited. At Mlomp dispensary in south-western Senegal, an area of moderate malaria transmission, year-round, clinically-suspected malaria was treated with monotherapy as per WHO and national policy in the 19...

journal_title：Malaria journal

authors： Brasseur P,Badiane M,Cisse M,Agnamey P,Vaillant MT,Olliaro PL

更新日期：2011-07-25 00:00:00

abstract：BACKGROUND:The ACT recommended by WHO is very effective and well-tolerated. However, these combinations need to be administered for three days, which may limit adherence to treatment.The combination of dihydroartemisinin-piperaquine phosphate-trimethoprim (Artecom®, Odypharm Ltd), which involves treatment over two days...

journal_title：Malaria journal

authors： Menan H,Faye O,Same-Ekobo A,Oga AS,Faye B,Kiki Barro CP,Kuete T,N'diaye JL,Vicky AM,Tine R,Yavo W,Kane D,Kassi KF,Kone M

更新日期：2011-07-08 00:00:00

abstract：BACKGROUND:Indoor-based anti-vector interventions remain the preferred means of reducing risk of malaria transmission in malaria endemic areas around the world. Despite demonstrated success in reducing human-mosquito interactions, these methods are effective solely against endophilic vectors. It may be that outdoor loc...

journal_title：Malaria journal

authors： Reddy MR,Overgaard HJ,Abaga S,Reddy VP,Caccone A,Kiszewski AE,Slotman MA

更新日期：2011-07-07 00:00:00

abstract：BACKGROUND:In formerly endemic areas where malaria transmission has declined, levels of population immunity to Plasmodium falciparum provide information on continued malaria transmission and potentially susceptible populations. Traditional techniques for measuring serological responses to P. falciparum antigens use pla...

journal_title：Malaria journal

authors： Chidi AP,Chishimba S,Kobayashi T,Hamapumbu H,Mharakurwa S,Thuma PE,Moss WJ

更新日期：2011-06-10 00:00:00

abstract：BACKGROUND:In insects, including Anopheles mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and Plasmodium or between Plasmodium berghei a...

journal_title：Malaria journal

authors： Smith PH,Mwangi JM,Afrane YA,Yan G,Obbard DJ,Ranford-Cartwright LC,Little TJ

更新日期：2011-06-08 00:00:00

abstract：BACKGROUND:The clinical use of mefloquine (MQ) has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs) that do not accumulate in the central nervous system (CNS) to the same extent may have utility. In this study, CNS levels of NGQMs relative to MQ were measured and an early le...

journal_title：Malaria journal

authors： Dow GS,Milner E,Bathurst I,Bhonsle J,Caridha D,Gardner S,Gerena L,Kozar M,Lanteri C,Mannila A,McCalmont W,Moon J,Read KD,Norval S,Roncal N,Shackleford DM,Sousa J,Steuten J,White KL,Zeng Q,Charman SA

更新日期：2011-06-06 00:00:00

abstract：:Recent WHO guidelines recommend a universal "test and treat" strategy for malaria, mainly by use of rapid diagnostic test (RDT) in all areas. The evidence for this approach is questioned here as there is a risk of over-reliance on parasitological diagnosis in high transmission situations, which still exist. In such ar...

journal_title：Malaria journal

authors： Graz B,Willcox M,Szeless T,Rougemont A

更新日期：2011-05-20 00:00:00

abstract：BACKGROUND:Increased control has produced remarkable reductions of malaria in some parts of sub-Saharan Africa, including Rwanda. In the southern highlands, near the district capital of Butare (altitude, 1,768 m), a combined community-and facility-based survey on Plasmodium infection was conducted early in 2010. METHO...

journal_title：Malaria journal

authors： Gahutu JB,Steininger C,Shyirambere C,Zeile I,Cwinya-Ay N,Danquah I,Larsen CH,Eggelte TA,Uwimana A,Karema C,Musemakweri A,Harms G,Mockenhaupt FP

更新日期：2011-05-18 00:00:00

abstract：BACKGROUND:Obtaining single parasite clones is required for many techniques in malaria research. Cloning by limiting dilution using microscopy-based assessment for parasite growth is an arduous and labor-intensive process. An alternative method for the detection of parasite growth in limiting dilution assays is using a...

journal_title：Malaria journal

authors： Butterworth AS,Robertson AJ,Ho MF,Gatton ML,McCarthy JS,Trenholme KR

更新日期：2011-04-18 00:00:00

abstract：BACKGROUND:As the ecology of mosquito larvae can be complex there is need to develop a rational framework for undertaking larval ecological studies. Local environmental characteristics, such as altitude, climate and land use, can significantly impact on phenology and population dynamics of mosquito larvae, and indirect...

journal_title：Malaria journal

authors： Imbahale SS,Paaijmans KP,Mukabana WR,van Lammeren R,Githeko AK,Takken W

更新日期：2011-04-10 00:00:00

abstract：BACKGROUND:Patterns of decreasing malaria transmission intensity make presumptive treatment of malaria an unjustifiable approach in many African settings. The controlled use of anti-malarials after laboratory confirmed diagnosis is preferable in low endemic areas. Diagnosis may be facilitated by malaria rapid diagnosti...

journal_title：Malaria journal

authors： Bastiaens GJ,Schaftenaar E,Ndaro A,Keuter M,Bousema T,Shekalaghe SA

更新日期：2011-04-02 00:00:00

abstract：:Natural compounds, mostly from plants, have been the mainstay of traditional medicine for thousands of years. They have also been the source of lead compounds for modern medicine, but the extent of mining of natural compounds for such leads decreased during the second half of the 20th century. The advantage of natural...

journal_title：Malaria journal

authors： Ginsburg H,Deharo E

更新日期：2011-03-15 00:00:00

abstract：:The outcomes from recent high profile deliberations concerning African health research and economic development all point towards the need for a mechanism to support health innovation on the continent. The mission of the African Network for Drugs and Diagnostics Innovation (ANDI), is to promote and sustain African-led...

journal_title：Malaria journal

authors： Addae-Mensah I,Fakorede F,Holtel A,Nwaka S

更新日期：2011-03-15 00:00:00

abstract：BACKGROUND:Prompt, quality assured laboratory diagnosis is key to effective malaria case management and control, especially since the introduction of the more expensive artemisinin combination therapy (ACT). The malaria programme and its non-government partners, on the basis of WHO recommended Lot Quality Assurance met...

journal_title：Malaria journal

authors： Khan MA,Walley JD,Munir MA,Khan MA,Khokar NG,Tahir Z,Nazir A,Shams N

更新日期：2011-02-17 00:00:00

abstract：BACKGROUND:Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P. malariae is more common than previously thought, and is frequently in sympatry and co-infection with P. falciparum, making its study increas...

journal_title：Malaria journal

authors： Bruce MC,Macheso A,McConnachie A,Molyneux ME

更新日期：2011-02-11 00:00:00

abstract：BACKGROUND:Species of anopheline mosquitoes are largely distributed over emerged lands around the world and, within the tropics, few areas are without these insects, which are vectors of malaria parasites. Among the exceptions is the Seychelles archipelago in the western Indian Ocean. However, in the Aldabra island gro...

journal_title：Malaria journal

authors： Robert V,Rocamora G,Julienne S,Goodman SM

更新日期：2011-02-08 00:00:00

abstract：BACKGROUND:Malaria prevalence has recently declined markedly in many parts of Tanzania and other sub-Saharan African countries due to scaling-up of control interventions including more efficient treatment regimens (e.g. artemisinin-based combination therapy) and insecticide-treated bed nets. Although continued molecula...

journal_title：Malaria journal

authors： Ishengoma DS,Lwitiho S,Madebe RA,Nyagonde N,Persson O,Vestergaard LS,Bygbjerg IC,Lemnge MM,Alifrangis M

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:The present study evaluated the SD Bioline Malaria Ag 05FK40 (SDFK40), a three-band RDT detecting Plasmodium falciparum-specific parasite lactate dehydrogenase (Pf-pLDH) and pan Plasmodium-specific pLDH (pan-pLDH), in a reference setting. METHODS:The SDFK40 was retrospectively and prospectively tested again...

journal_title：Malaria journal

authors： Maltha J,Gillet P,Cnops L,Bottieau E,Van Esbroeck M,Bruggeman C,Jacobs J

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Individual malaria interventions provide only partial protection in most epidemiological situations. Thus, there is a need to investigate whether combining interventions provides added benefit in reducing mortality and morbidity from malaria. The potential benefits of combining IPT in children (IPTc) with ho...

journal_title：Malaria journal

authors： Sesay S,Milligan P,Touray E,Sowe M,Webb EL,Greenwood BM,Bojang KA

更新日期：2011-01-07 00:00:00